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1

Targeting mutant p53 for efficient cancer therapy

Bykov, Vladimir J. N., Eriksson, Sofi E., Bianchi, Julie, Wiman, Klas G.

Journal:

Nature Reviews Cancer

Year:

2017

Language:

english

File:

PDF, 638 KB

english, 2017

2

p53 in the Clinics || Genetic Counseling for TP53 Germline Mutations

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 319 KB

english, 2013

3

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

Hayday, Adrian C., Gillies, Stephen D., Saito, Haruo, Wood, Charles, Wiman, Klas, Hayward, William S., Tonegawa, Susumu

Journal:

Year:

1984

File:

PDF, 957 KB

1984

4

What is the restriction point?

Anders Zetterberg, Olle Larsson, Klas G Wiman

Journal:

Current Opinion in Cell Biology

Year:

1995

Language:

english

File:

PDF, 919 KB

english, 1995

5

25 Years of p53 Research ||

Hainaut, Pierre, Wiman, Klas G.

Year:

2005

Language:

english

File:

PDF, 11.22 MB

english, 2005

6

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.

Journal:

Frontiers in Oncology

Year:

2016

Language:

english

File:

PDF, 635 KB

english, 2016

7

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

Lindström, Mikael S, Klangby, Ulf, Wiman, Klas G

Journal:

Year:

2001

Language:

english

File:

PDF, 517 KB

english, 2001

8

The feasibility of the pixe technique in the analysis of stamps and art objects

Eva-Marta Johanson, Sven A.E. Johanson, Klas G. Malmqvist, Ingela M.B Wiman

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

1986

Language:

english

File:

PDF, 527 KB

english, 1986

9

PRIMA-1met radiosensitizes prostate cancer cells independent of their MTp53-status

Stéphane Supiot, Helen Zhao, Klas Wiman, Richard P. Hill, Robert G. Bristow

Journal:

Radiotherapy and Oncology

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

10

Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

Selivanova, Galina, Ryabchenko, Ludmila, Jansson, Emmelie, Iotsova, Violetta, Wiman, Klas G.

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 876 KB

english, 1999

11

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Xu, Dawei, Wang, Qian, Gruber, Astrid, Björkholm, Magnus, Chen, Zhiguo, Zaid, Ahmed, Selivanova, Galina, Peterson, Curt, Wiman, Klas G, Pisa, Pavel

Journal:

Year:

2000

Language:

english

File:

PDF, 334 KB

english, 2000

12

Identification of functional p53-binding motifs in the mouse wig-1 promoter

Margareta T Wilhelm, Cristina Méndez-Vidal, Klas G Wiman

Journal:

Year:

2002

Language:

english

File:

PDF, 198 KB

english, 2002

13

p53 in the Clinics || TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 528 KB

english, 2013

14

Mutant p53 reactivation by small molecules makes its way to the clinic

Bykov, Vladimir J.N., Wiman, Klas G.

Journal:

Year:

2014

Language:

english

File:

PDF, 479 KB

english, 2014

15

Novel cancer therapy by reactivation of the p53 apoptosis pathway

Bykov, Vladimir, Wiman, Klas

Journal:

Annals of Medicine

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

16

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts

Lindström, Mikael S, Wiman, Klas G

Journal:

Year:

2003

Language:

english

File:

PDF, 503 KB

english, 2003

17

The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs

Cristina Méndez Vidal, Magdalena Prahl, Klas G. Wiman

Journal:

Year:

2006

Language:

english

File:

PDF, 1.99 MB

english, 2006

18

p53 in the Clinics || p53 in the Clinic: A Pathologist’s View

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 695 KB

english, 2013

19

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Peng, Xiaoxiao, Zhang, Mei-Qiong-Zi, Conserva, Francesca, Hosny, Gihan, Selivanova, Galina, Bykov, Vladimir JN, Arnér, Elias SJ, Wiman, Klas G

Journal:

Cell Death and Disease

Year:

2017

Language:

english

File:

PDF, 188 KB

english, 2017

20

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

Selivanova, Galina, Iotsova, Violetta, Okan, Ismail, Fritsche, Michael, Ström, Marika, Groner, Bernd, Grafström, Roland C., Wiman, Klas G.

Journal:

Nature Medicine

Year:

1997

File:

PDF, 894 KB

1997

21

A Novel High-Through-Put Assay for Screening of Pro-Apoptotic Drugs

Maria Hägg, Kenneth Bivén, Takayuki Ueno, Lars Rydlander, Peter Björklund, Klas G. Wiman, Maria Shoshan, Stig Linder

Journal:

Investigational New Drugs

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

22

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

23

p14ARF Deletion and Methylation in Genetic Pathways to Glioblastomas

Mitsutoshi Nakamura, Takao Watanabe, Ulf Klangby, Charlotte Asker, Klas Wiman, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgaki

Journal:

Brain Pathology

Year:

2001

Language:

english

File:

PDF, 267 KB

english, 2001

24

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Bykov, Vladimir J.N., Issaeva, Natalia, Shilov, Alexandre, Hultcrantz, Monica, Pugacheva, Elena, Chumakov, Peter, Bergman, Jan, Wiman, Klas G., Selivanova, Galina

Journal:

Nature Medicine

Year:

2002

Language:

english

File:

PDF, 1.96 MB

english, 2002

25

Immunolocalization of Human p14ARF to the Granular Component of the Interphase Nucleolus

Mikael S. Lindström, Ulf Klangby, Rie Inoue, Pavel Pisa, Klas G. Wiman, Charlotte E. Asker

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 378 KB

english, 2000

26

25 Years of p53 Research || Novel p53-Based Therapies: Strategies and Future Prospects

Hainaut, Pierre, Wiman, Klas G.

Year:

2007

Language:

english

File:

PDF, 818 KB

english, 2007

27

New p53-based anti-cancer therapeutic strategies

Journal:

Medical Oncology

Year:

1998

Language:

english

File:

PDF, 738 KB

english, 1998

28

Occurrence of Ia antigens on tissues of non-lymphoid origin

WIMAN, KLAS, CURMAN, BENGT, FORSUM, URBAN, KLARESKOG, LARS, MALMNÄS-TJERNLUND, ULLA, RASK, LARS, TRÄGÅRDH, LENA, PETERSON, PER A.

Journal:

Year:

1978

File:

PDF, 315 KB

1978

29

Role of Thiol Reactivity for Targeting Mutant p53

Zhang, Qiang, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.

Journal:

Cell Chemical Biology

Year:

2018

Language:

english

File:

PDF, 2.12 MB

english, 2018

30

Reactivation of mutant p53: a new strategy for cancer therapy

Galina Selivanova, Takashi Kawasaki, Ludmila G. Ryabchenko, Klas G Wiman

Journal:

Seminars in Cancer Biology

Year:

1998

Language:

english

File:

PDF, 329 KB

english, 1998

31

p53 Binds Single-Stranded DNA Ends and Catalyzes DNA Renaturation and Strand Transfer

Georgy Bakalkin, Tatjana Yakovleva, Galina Selivanova, Kristinn P. Magnusson, Laszlo Szekely, Elena Kiseleva, George Klein, Lars Terenius and Klas G. Wiman

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.47 MB

english, 1994

32

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

Hellborg, Fredrik, Qian, Wang, Mendez-Vidal, Cristina, Asker, Charlotte, Kost-Alimova, Maria, Wilhelm, Margareta, Imreh, Stefan, Wiman, Klas G

Journal:

Year:

2001

Language:

english

File:

PDF, 682 KB

english, 2001

33

p53-Induced Apoptosis as a Safeguard against Cancer

Charlotte Asker, Klas G. Wiman, Galina Selivanova

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 55 KB

english, 1999

34

p53 in the Clinics || TP53 Germline Mutations: Genetics of Li–Fraumeni Syndrome

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 283 KB

english, 2013

35

Purification and partial amino acid sequence of papain-solubilized class II transplantation antigens

Wiman, Klas, Claesson, Lena, Rask, Lars, Traegaardh, Lena, Peterson, Per A.

Journal:

Year:

1982

Language:

english

File:

PDF, 1.71 MB

english, 1982

36

p53 as a target for improved cancer therapy

Journal:

Expert Opinion on Therapeutic Targets

Year:

1999

Language:

english

File:

PDF, 55 KB

english, 1999

37

Regulation of tumor suppressor p53 at the RNA level

Anna Vilborg, Margareta T. Wilhelm, Klas G. Wiman

Journal:

Journal of Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 242 KB

english, 2010

38

An old acquaintance resurfaces in human mesothelioma

Wiman, Klas G., Klein, George

Journal:

Nature Medicine

Year:

1997

File:

PDF, 226 KB

1997

39

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells

Rippin, Thomas M, Bykov, Vladimir J N, Freund, Stefan M V, Selivanova, Galina, Wiman, Klas G, Fersht, Alan R

Journal:

Year:

2002

Language:

english

File:

PDF, 1.06 MB

english, 2002

40

Similarities between Immunoglobulins and Transplantation Antigens in Amino-Acid Sequence and Disulfide-Bond Distribution

Klas WIMAN, Lena TRÄGÅRDH, Lars RASK, Per A. PETERSON

Journal:

Year:

1979

Language:

english

File:

PDF, 867 KB

english, 1979

41

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival

Paul, Esbjörn, Paul, Esbjörn, Uggla, Bertil, Deneberg, Stefan, Bengtzen, Sofia, Hermansson, Monica, Dahlman, Ingrid, Rosenquist, Richard, Wiman, Klas G., Nahi, Hareth

Journal:

Leukemia and Lymphoma

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

42

EBNA-5, an Epstein-Barr Virus-Encoded Nuclear Antigen, Binds to the Retinoblastoma and p53 Proteins

Laszlo Szekely, Galina Selivanova, Kristinn P. Magnusson, George Klein and Klas G. Wiman

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.32 MB

english, 1993

43

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.

Journal:

Frontiers in Oncology

Year:

2018

Language:

english

File:

PDF, 2.77 MB

english, 2018

44

The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA

Magdalena Prahl, Anna Vilborg, Carina Palmberg, Hans Jörnvall, Charlotte Asker, Klas G. Wiman

Journal:

Year:

2008

Language:

english

File:

PDF, 569 KB

english, 2008

45

p53 splice acceptor site mutation and increased HsRAD51 protein expression in Bloom's syndrome GM1492 fibroblasts

Kristinn P. Magnusson, Margareta Sandström, Margareta Ståhlberg, Maria Larsson, Jenny Flygare, Dennis Hellgren, Klas G. Wiman, Siv Ljungquist

Journal:

Year:

2000

Language:

english

File:

PDF, 236 KB

english, 2000

46

[Part 2: Biological Sciences] || Complete Amino Acid Sequence of Pooled Papain-Solubilized HLA-A, -B, and -C Antigens: Relatedness to Immunoglobulins and Internal Homologies

Lena Trägårdh, Lars Rask, Klas Wiman, Jan Fohlman and Per A. Peterson

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 985 KB

english, 1980

47

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G

Journal:

Journal of Molecular Cell Biology

Year:

2019

Language:

english

File:

PDF, 1.54 MB

english, 2019

48

p53 in the Clinics || The p53 Family and Stem Cell Biology

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 415 KB

english, 2013

49

p53 in the Clinics || TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer

Hainaut, Pierre, Olivier, Magali, Wiman, Klas G.

Year:

2013

Language:

english

File:

PDF, 369 KB

english, 2013

50

[Part 1: Biological Sciences] || Activation of the C-myc Gene by Translocation: A Model for Translational Control

Haruo Saito, Adrian C. Hayday, Klas Wiman, William S. Hayward and Susumu Tonegawa

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 1.23 MB

english, 1983

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